Roger,
Flying up through Canada will likely be amenable to your wife. The typical stops above Edmonton (Whitecourt, Grand Prairie, Dawson Creek, Fort St. John, Fort Nelson, Teslin, Haines Junction, Watson Lake, Whitehorse, or some combination of those) all have decent hotels and good airports. In Canada every small town with an airport has taxi service though it is usually a bit more expensive than you might be used to. Most have camping on the field too if you think that would work.
Once you get up here in state you can go to the bush, or do lots of flights along the highways and "civilization", or do a little of both. To keep your wife happy you can fly to Talkeetna (PATK), McKinley Park (PAIN), Fairbanks, Palmer, Glenallen, down into the Kenai (Homer, Seward, Ninilchik, Soldotna etc.), still have some great flying, and yet be on long runways and be near lodges, bed and breakfasts or hotels each night if that is what maintains marital relations

If you are feeling adventurous you can fly some places off the road system (McGrath maybe, or Galena, or Port Allsworth, or Chena Hot Springs) and still have cabins or lodges to choose from.
You won't need O2 unless you are flying up around Mt. McKinley! You never want to fly over the top of any weather up here, too many pointy things sticking through the soup and never any guarantee you will find a way back down. Plus it's generally not allowed in Canada. Plan on doing a lot of flying 500-2000 agl.
Does your family all have passports? They are required to get back into the US from Canada now, even just flying to Alaska.
Here is one I might do, based on what you said. Northway>Anchorage>Homer(fish)>Seward(sea life center)>Anchorage>Talkeetna(spend a couple days here)>McKinleyPark (spend a couple days here doing the tourist thing)>Fairbanks(spend a few days here taking some day flights off the beaten path - Coldfoot? Chena Hot Springs? Galena? Lake Minchumina? Kantishna?)>back to Canada. MAybe stop in Eagle on the way through. If weather is nice shoot down the highway from Haines Junction in the Yukon, reenter the US and visit Haines or Skagway, and maybe fly down to Gustavus, or Juneau. Back up to Haines Junction and then head home.
Here is some advice that I give people, that somewhat conflicts what I wrote above. Too many people spend all their time up here driving (or in some cases flying) and not enough time sitting back and smelling the Forget-me-nots (state flower), if you know what I mean . With the loooooong days it's easy to get in the habit of go, go, go without enjoying yourself. You will be taking a long flight already to get up here, and to get back, with multiple stops.
Less destinations, more time on the ground to enjoy yourself, I say.
Oh yeah, if you want to spend the money you can put the wife and kids on the train that runs between Seward and Fairbanks, and pick them up somewhere else, so you can have the plane to yourself for a while. The best section is between Talkeetna and Denali Park (the airports are right next to the train depot at both places), or maybe Anchorage and Denali Park.
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