Love the Lake Amphib. Shortly after acquiring my PPL, I bought a LA4-200 from Lake Central Air Services in Muskoka, Ontario. I completed the factory training course with some very experienced Lake pilots who put me through all of the paces, and I then spent the first summer flying it across Canada, covering the vast Northlands from Goose Bay, Labrador to Tuktoyaktuk, NWT. One of the best experiences of my life, and fantastic way to learn about backcountry and bush flying.
Several years, many adventures, and 529h logbook hours later, I sold FHNT and bought a Mooney Ovation because my mission had changed from 'get there fun' to 'get there fast', but I still look back on my time in the Lake as a big part of my 'how i became a pilot' story. No other airplane--even the Cessna 185 that I now fly--required as much attention or demanded as much proficiency.
There is no doubt that Lakes aren't for everyone, and they have a very specific mission profile and more than enough quirks. This makes them personal aircraft, rather than working bush planes, but there's very few places that you can't go with a Lake, and you'll rarely have more fun getting there.

