I've put ACK 406 beacons in two airplanes now, and I'd go there again in a heartbeat. Installing a 121.5 beacon makes absolutely no sense these days....don't go there.
The ACK is the least expensive unit out there, I believe. Yes, it requires a wire to your GPS source, or you could mount a remote "dumb" GPS on the same rack as the Beacon. Running wires is a PITA, indeed, but EVERY 406 ELT is going to have a remote switch, that goes on the panel, and that is connected by wires to the box back aft.
I inadvertently tested my ACK unit once. It was hooked to a Garmin 396. I received a phone call in just a couple minutes from RCC. Out of curiousity, I asked them if they'd got a lat/long location from the beacon. They said wait one, and a few minutes later, he came back with a location that had to have been within feet of my location.
I'd bet the ACK is installed in more airplanes now than all the other 406 beacons together.
MTV