We are talking Wagons here, so here is what I've learned (mostly from persons more experienced then I):
If you're flying has a single mission there is a perfect tire/wheel combination. But if your flying has two missions, there is not a perfect tire/wheel, you will need to compromise. Have more then two missions? Then there will need to be even more compromise. The exact compromise will be based on what percent each of the missions is to the whole - and your emotion - in other words to what extent you want a coolness factor. And of course what that means to you. And perhaps your budget.
Choose poorly and you won't like the results. If you put ghetto tires and wheels (the biggest wheel shortest sidewall tire) on your 4x4 and take it off road, your vehicle will hate you, your body will hate you, and your pocket book will hate you.
Put a small rim, large sidewall tire on your sports car, drive it fast, and corners will hate you. Race Mulholland Drive for pinks and you'll be walking home, assuming you don't perish in a fiery crash over a cliff.
What does all this mean for a Wagon?
Put 8.00x6 on the mains, with speed pants and a speed kit, and you've got one sexy, very fast, pavement pounder.
Take off the speed pants, put on 8.50x6, and you've got a not quite so fast (but still envious), pavement/grass strip/wet beach sand player that looks a bit underdressed.
Put on Goodyear Blimp 26x6 and you retain essentially the same speed as the 8.50x6, have a little better flotation in the soft stuff, no tread so you throw less at the wing and tail, and they wear like iron on pavement. They are tube type tires so can't be aired down as low as bushwheels without spinning the tire on the rim and shearing the valve stem (try putting contact cement on the bead). Their sidewalls are stiffer (because they wear like iron) then 26" Bushwheels so they don't cushion the same.
Put on 26x6 Bushwheels and you loose some speed because they are both taller and wider then 26x6 Goodyear Blimp tires. They have better cushion and flotation (because they are both taller and wider, and can be aired down lower), but they don't wear like iron. However the coolness factor is significantly improved with either 26's.
Put on 29x6 Bushwheels and loose a lot of speed (15mph on my Wagon). Very good cushion and flotation, but they don't wear like iron. And a little sidewall tucking on sidehills. Excellent rough country, off-airport tire/wheel size. Unbeatable coolness factor - until you park next to a wagon with 31's.
Put on 29x10 Airhawks and you are going a little Ghetto (shorter sidewall height), so you'll have less cushion, but it will also have less sidewall tuck. And perhaps be a little better on pavement.
Put 31x6 Bushwheels on and hopefully you have RSTOL and never land on side hills (otherwise why have them - oh yea - the coolness factor). Of course this combo might be perfect for that single mission plane.
Except for single missions there is no perfect tire/wheel combination, nor is there an imperfect tire/wheel combination. They all have there place and so all have equal value. IMHO anyway.
Coolness can always weight or even trump mission (or practicality) - as can budget.