There are at least as many designs of float trailers as there are seaplanes.
First, what do you NEED?
Do you need to be able to pick a seaplane out of the water, move it to a hangar or storage on land, drop it there, and pick another? Coming back later to pick up that same plane, and put it in the water? If so, that will indeed require a system that can lift the plane and lower it.
Otherwise, if you can live with a trailer, just to move a plane in and out of the water, build a low deck trailer...simple and cheap.
BUT, assuming you do need to lift and drop, and re-lift:
Obviously, if you need to go this route, lifting via the keels is impossible. So, lifting via the spreaders is required. Problem is, unless you are designing this for only one airplane, you have to accommodate the different widths of spreader bars. You mentioned Cub and 185, for example. The spreaders on those planes are very different lengths. Also, the distance BETWEEN spreader bars differs greatly as well.
As WW noted, using a relatively narrow lifting system on the spreaders places a lot of bending moment on the spreaders....not good. So, making a system that fits several types can be a challenge, and takes some thought.
The system I liked best was a lift system, with an adjustable WIDTH spreader bar lift system. This can be done by setting the portion of the device that actually contacts the spreaders up with a sliding adjustment for width. For the rear spreader lift, a fixed (fore and aft) rail, with sliding channel iron pieces, padded with wood to protect the spreader bar, works well.
The tough one is the front one, which has to be adjustable in both width AND fore and aft. That gets more complicated, but just requires one more "level" of support. Or, you can simply make the lift bar for the front spreader bar long enough fore and aft to accommodate all comers.....or design BOTH spreader lifts wide enough.....potential slipping, however......
All of this mish-mash is then mounted on a parallelogram type hydraulic lift arrangement, with a single lifting ram.
You can mount this on a low trailer chassis, in which case you'll need to ensure that the axle width is narrow enough to fit between the floats of the narrowest plane you plan to lift.
Which, of course, and as WW noted, can make for a pretty wobbly setup, particularly if you have to move over anything other than paved or concrete ramps......
The absolute best of these kinds of systems I've seen are like Burl Rogers uses at Lake Hood Seaplane base in Anchorage. Burl built a system like I have described, but instead of building it on a trailer chassis, he found an old Jeep pickup, and welded the seaplane lifting "trailer" to the front frame rails of the Jeep, so that the "trailer" is now a solid part of the pickup's chassis. He then removed the portion of the Jeep aft of the cab. In other words, he sawed off the Jeep's frame rails just behind the cab, and removed all the drive train components aft of the transfer case. Now, the thing is in four wheel drive all the time, driving only the front wheels, of course, but the Jeep itself stabilizes the lifting system greatly. He can lift (with adjustable spreader lifts, as noted) almost any size seaplane quickly and then set them down in his hangar for maintenance or on the bank for the winter. Then, pick them up from land later, and plunk them in the water.
A nice system, but as you probably have figured, it's "busy", and is going to take some work. Simplest system is to just build a low deck trailer, but then getting planes onto and off the trailer from land is tough.
In any case, if you are a welder and you've got some time, I'd just do some measuring on the planes you want to move, sit down and think about how it'll have to work (two frames, one that has the axles and hydraulics, the other that does the lifting with a scissors or ?) and the spreader bar contact points. Then draw it out, and build it.
If you happen to have an old four wheel drive vehicle around somewhere, and you plan to lift a lot of seaplanes, you might consider the rig like Burl uses. It's really stable. If you can pretty much stay on level surfaces, then a trailer lift system can work as well.
Good luck.
MTV