Really bare bones IFR can be done with one nav/com and a transponder. I've done it. But I don't recommend it. The workload can get horrendous on some approaches.
GPS approaches and enroute travel are the wave of the future, but they're here now. Going direct is as common as flying the airways, maybe more common in some areas of the country, And you can get in with a GPS WAAS RNAV approach to as tight an approach as an ILS. For instance, at my airplane's home drome Greeley, the ILS 35 minimums are 3/4 mile and 200'. The RNAV (GPS) 35 minimums are (drum roll) 3/4 mile and 200'. But in addition to the ILS and GPS to 35, there are similar approaches to 10, 17, and 28. The minimums for 10 are 3/4 mile and 250', but the others are both 3/4 mile and 200'. That's a whole lot better than the VOR-A approach, which is 1 mile and 700'. You'll find the same comparisons at Pocatello, Idaho Falls, Twin Falls, Boise, and a host of other airports.
But there are gobs of small airports around the country which only have GPS approaches--if you're going into one of them IFR, you must have an approach certified GPS; e.g., McCall, Caldwell (it still has an NDB, too), Nampa (also has an NDB), Grangeville, etc.
There are still some airports here and there with NDB approaches only. At the time I had my ADF installed, there were enough to justify it, but most of those have since been converted to GPS approaches. There are airports, such as Cheyenne, which have all the approaches, ILS, GPS, NDB, and VOR. There are a few airports around the country which require DME--Grand Island has a back course localizer (BC/LOC) which requires a DME.
But you can do all of these with an approach certified GPS/nav/com such as the 430W or 650. They aren't cheap, and the annual cost of updates is a factor--my annual cost for the entire US for my 430W is $425.
If on the other hand, you're not concerned about approaches at all, and you only want enroute IFR capabilities, you can still get by with a single nav/com and a transponder, and a 6 pack. Your airplane will have to be IFR certified, which means a pitot/static check and transponder check every 2 years, which should run about $500 or so. It'll be awhile before VORs are shut down and Victor airways go away, and it's still entirely possible to navigate electronically everywhere in the country via VOR. You need to make sure that if you're going to fly in the clouds, though, that you can get down through them, and as we all know, weather isn't entirely predictable. In fact, that's what persuaded me to have the 430W installed, because it was only by chance that I was able to get into an airport VFR through a hole in the clouds, which had a VOR approach and a GPS approach, but the VOR had gone down an hour before I got there.
With all that is happening in the avionics world these days, though, I'd wait until your airplane is completely built before deciding on the avionics. What is state of the art today may be an antique by then.
Cary




