I read every scrap of paper EAA published on the subject before "intalling" the autofuel STC on my aircraft. They've tested EVERY fuel additive allowed in the USA, and all are approved under the STC EXCEPT alcohol of any kind. And even that allows 1% acohol, which works out to 1 pint bottle of Heat per 12.5 gals of fuel.
The primary problem EAA found, was not with the rubber seals and hoses, (though that is a problem) but with water. The alcohol keeps the water in suspension, so you can't detect it, or drain it from your sumps. But then, as you climb to higher altitudes with lower pressures and temperatures, the water can fall out of suspension again. Resulting in engine failure.
Another side effect of the alcohol bonding with water is that it dramatically lowers the octane rating of the fuel. Apparently this can be enough to cause detonation. They site severe cases were float planes refueled at marina's, where alcohol had been added to absorb water in the tanks, only to have all 4 pistons punched out on takeoff. Yikes!
Testing is very easy. I use a 1 liter soda bottle. It's got a mark at the 100ml level. I fill to that mark with water, then fill the rest of the way with the fuel to be tested. Shake the holy heck out of it and watch it settle. If there's no alcohol in it, the water settles out again in a couple seconds, and there the same amount you started with. If there is alcohol, it takes several minutes to settle out again, and there appears to be more water than you started with. I did a test, got a negative, and added 50ml (5%) Heat alcohol and tried it again just to see the difference. Believe me, it's a dramatic difference. Better yet, don't believe me, try it yourself.
Cars don't have these problems because 1. They rarely change altitude by thousands of feet in a few minutes. 2. They have electronic knock sensors that automatically retard the timing. 3. They have circulating fuel injection systems, so a slug of water in the fuel line goes past the injectors causing no more than a momentary miss. This same system also heats the fuel a little helping keep an alcohol/water mix in suspension.
Water is probably why boaters were the first to have problems with alcohol blend fuels, they're the ones most likely to get water in their fuel.
I've read that modern autofuel blends don't have the varnish problems anymore either. And I let an old truck sit for 3 years with the same fuel, no problems, so it seems to be true. But I still won't run fuel, auto or av, that's more than a couple months old in my plane.
Anyway, EAA has pages and pages on this subject and the results of their testing in the members section of their web site. I know, I spent a couple days reading through all of it before using auto fuel in my plane.
Phil